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Jul 24, - But Lybridos contains testosterone and the antidepressant buspirone, a drug already on the market and known to reverse the negative sexual side effects of antidepressants in some cases by modifying changed levels of the neurotransmitter serotonin that cause the sexual dysfunction. May 1, - paroxetine (Paxil) Still another option is buspirone (BuSpar), which may restore the ability to have an orgasm and "Sexual Dysfunction Associated with Antidepressant Therapy," Urologic Clinics of North America (Nov.