Columbia’s last liftoff, January 16th, 2003.
Columbia was the first shuttle to fly; a short, two-day mission in 1981. She was also the first shuttle with a female commander. Over the orbiter’s life, Columbia spent nearly 301 days in space and flew over 125,000,000 miles. She is also the only shuttle to have never visited Mir or the ISS (aside from Challenger, which was lost before the stations were operating, and Enterprise which never flew in space) as Columbia wasn’t suited for high-inclination missions.
The ship was lost with all hands on reentry, February 1st, 2003. During launch, a piece of insulating foam broke off the external fuel tank and struck Columbia’s wing, damaging it. Upon reentry, hot gases entered the wing, damaging the support structure, which spread to the rest of the ship, causing it to disintegrate.